![]() However, the effect on sleep varies between compounds within antidepressant classes, differences relating to the amount of sedative or alerting (insomnia) effects, changes to baseline sleep parameters, differences relating to REM sleep, and the degree of sleep-related side effects. REM sleep suppression has been observed with all TCAs except trimipramine, but especially clomipramine, with all MAOIs and SSRIs and with venlafaxine, trazodone and bupropion. Abstract Objective To assess the efficacy and tolerability of trazodone compared with placebo in patients with insomnia. Methods.A literature search was conducted using MEDLINE/PubMed databases from the past 33 years (19832016) and the keywords insomnia, trazodone, sedative, treatment, and hypnotics. Sedation has been reported with all TCAs except desipramine, with mirtazapine and nefazodone, the TCA-related maprotiline, trazodone and mianserin, and with all MAOIs. In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. Insomnia is often seen with monoamine oxidase inhibitors (MAOIs), with all tricyclic antidepressants (TCAs) except amitriptyline, and all selective serotonin reuptake inhibitors (SSRIs), as well with venlafaxine and moclobemide. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. If you are 65 or older, use this medicine (trazodone tablets) with care. Nevertheless, the distinction is made between those studies, because the participant’s health may influence the baseline sleep profiles and the effect of the antidepressant. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. RCTs are not restricted to depressed populations, since several studies provide useful information about the effects on sleep in other groups. This systematic review examines randomised-controlled trials (RCTs) that have reported the effect that antidepressants appear to have on sleep. The extent of variation between the effects of antidepressants and sleep may relate to their mechanism of action. Current evidence suggests that this effect depends on the class of antidepressant used and the dosage. The current preliminary, open-label, randomized trial suggests that trazodone, but not CBT-I, significantly improves objective sleep duration and reduces. Given the relationship between sleep and depression, there is inevitably going to be an effect of antidepressants on sleep.
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